Venice's station area is safe, with good hotels.

Hotel ai Due Fanali roof terrace

Venice's Santa Lucia train station is on the edge of the historic center, alongside the Grand Canal.

At the station's "Ferrovia" ACTV stop, you can catch water buses to most places in Venice.

On foot, you can reach the major sights (including Piazza San Marco) in 30 minutes or so.

The station area is well served by hotels in various price categories:

0 bridges to cross:

 

1 high bridge (Ponte dei Scalzi) to cross:

2 bridges to cross (but worth the 10-minute walk):